Discovering an unknown cause of dementia | Middle east


Finding an unknown cause of dementia

Wednesday – 3 Rajab 1444 AH – January 25, 2023 AD


X-rays showing a “cerebrospinal fluid fistula” (Translation Research & Clinical Intervention)


Cairo: Hazem Badr


A research team from Cedars-Sinai Medical Center Hospital in America was able to discover an unknown cause for one of the most prominent types of dementia, which is “frontotemporal dementia.”
This type of dementia deprives patients of the ability to control their behavior and deal with daily life, as they suffer from severe cognitive, behavioral and personality changes, to the point that they must be placed in nursing homes.
One of the causes of the disease is a leakage of cerebrospinal fluid, which circulates in and around the brain and spinal cord, to help protect them from injury. When this fluid leaks into the body, “brain sagging” can occur, causing symptoms of dementia.
And when the fluid leaks through a rupture in the surrounding membrane, it is visible on a computerized tomography scan of the spinal cord with the help of a contrast medium, and thus this condition can be treated, but the new discovery of the research team, and it was published Tuesday in the journal “Translation Research & Clinical Intervention”, that there is An additional cause of cerebrospinal fluid leakage is a “venous cerebrospinal fluid fistula.” In these cases, fluid leaks into a vein, making it difficult to see on a routine CT scan of the spinal cord. To detect these leaks, technicians must use specialized CT scans and monitor the contrast medium. during its movement and during its flow through the cerebrospinal fluid.
In this study, the researchers used imaging technology on 21 patients with sagging brain and symptoms of “frontotemporal dementia”, and discovered a “venous cerebrospinal fluid fistula” in nine of these patients, and the leakage was closed surgically in all nine patients, which helped treat Brain sagging and associated symptoms of dementia.
“Such specialized imaging is not widely available, and this study suggests the need for more research to improve detection and cure rates for patients,” said Keith Black, chief of neurosurgery at Cedars-Sinai Medical Center, in a report published on the center’s website, coinciding with the study’s publication.
“Considerable efforts need to be made to improve the detection rate of CSF leaks in these patients. Therapies have been developed to manage the symptoms, but as our study showed, these therapies are much less effective than targeted surgical correction of the source of the leak.”



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