Farewell to diet programs…Scientists discover the genes of “thinness”!


It seems that obesity will no longer be an obsession for many, as there is no need for harsh diet programs, as a new study revealed that 16 rare genetic variants can prevent infection and prevent serious problems.

Researchers at the US company “Regeneron” conducted “whole-exome sequencing”, a comprehensive genetic test that searches for thousands of genes simultaneously, on more than 645,000 people from Britain, America and Mexico.

The researchers succeeded in identifying 16 variables that affect the body mass index (BMI), which determines whether a person is of normal weight, overweight or obese.

lower body mass index

They also found that there is a link between rare mutations in one of the genes, called GPR75, and protection against obesity.

It turns out that people who carry one inactive copy of GPR75 weigh about 5.5 kg less than the other people, and they face a 54% lower risk of obesity.

“The discovery of protective genetic superpowers, such as in GPR75, offers hope in the fight against complex and pervasive global health challenges such as obesity,” said George Yankopoulos, President and Chief Scientific Officer of Regeneron.

He added that the “exome” is a piece of DNA that contains 22,000 genes for a person, and it represents only 1% of the genome, but it contains most of the basic information for diagnosing inherited conditions.

Also, the GPR75 mutation, which is a G protein-coupled receptor, is found in approximately four out of every 10,000 people sequenced.

The researchers validated the findings in mice that had been genetically modified with copies of the GPR75 gene. , which gained 44% less weight compared to the other mice, whose mutation was not stimulated, even though both groups were fed a high-fat diet.

Terrifying indicators

Recent studies have revealed that 1.9 billion adults worldwide are overweight (with a BMI between 25 and 29.9) and 650 million are obese (with a BMI of 30 or more).

According to the World Health Organization, being overweight or obese leads to about 2.8 million deaths annually.

It is also estimated that about 57 percent of the global adult population will be overweight or obese by 2030.

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