New study on the mechanisms of natural immunity against malaria


Abu Dhabi:
New York University Abu Dhabi revealed the results of a study conducted under the supervision of Youssef Edgdour, Assistant Professor in the Department of Biology at the university, and in cooperation with researchers from the National Center for Research and Training on Malaria in Burkina Faso, which revealed a new molecular mechanism responsible for changing the body’s immune response to malaria infection, based on To the largest set of metabolic data obtained from blood samples of African children, from different ethnic groups, before and after malaria infection. The study contributed to understanding the molecular mechanisms affected during malaria infection, and demonstrated the importance of studying ethnic differences in response to infection, in clarifying the sources of susceptibility or resistance to infection.
The study, published in the journal Nature Metabolism, entitled “The Impact of Metabolic Disorders on the Acquired Immunity of Malaria in Humans”, provides valuable new information in this field that has not been sufficiently researched outside the laboratory, where not much information is available about the interactions of the malaria parasite. In the human body, especially in children who represent the age group most vulnerable to the effects of the disease. The team studied blood samples of children from the Gwen and Fulani ethnic groups in the remote villages of Burkina Faso, to see how their bodies responded to malaria parasites. Malaria is less likely to have a reversible response to steroid molecules and a stronger immune response to infection.
“The comparison between ethnic groups indicates that there is a basic molecular mechanism that determines the course and outcome of infection in children, and it is surprising that there is such a wide functional difference between two ethnic groups, which helped us discover one of the causes of natural resistance to malaria,” Edgdour said.
“These findings will change our understanding of how to develop better treatments for malaria and enhance the response of different ethnic groups to vaccines,” said Wael Abd Rabbo, first author of the research paper.
“These findings demonstrate the importance of taking ethnic diversity into account in our studies to better understand disease mechanisms,” said Issiaka Solama, principal investigator of the medical team in Burkina Faso.


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