Everton striker Richarlison scored the lead for the samba team in the 65th minute, with a powerful shot that goalkeeper Alexander Dominguez could not prevent.
Neymar was able to confirm the victory, after scoring a penalty in stoppage time after dropping his colleague Gabriel Jesus, and the referee pointed to the penalty mark after consulting the video assistant referee.
Although Neymar failed in his first attempt, which was saved by Ecuador goalkeeper Dominguez, the referee ordered the kick to be retaken because the goalkeeper advanced from the goal line at the moment of the shot.
With this victory, Brazil continued to lead the group with a full score with a score of 15 points from 5 matches, ahead of second-placed Argentina by 4 points, and Ecuador remained in third place with 9 points, noting that the Ecuadorean team won three of its previous four matches in the qualifiers.
The top four teams will qualify directly for the 2022 World Cup in Qatar, and the fifth-placed team will go to the playoffs.
Brazil is scheduled to face Paraguay in Asuncion on June 8, while Ecuador will play at home against Peru on the same day.