Corona and human cells … a simulation to solve the link puzzle

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Cairo – By Iman Abdullah – Supercomputer simulations show that the predominant variant of the Coronavirus is more contagious due to its greater ability to bind to human cells.

The results of these research, led by a research team from the Los Alamos National Laboratory, affiliated to the US Department of Energy, highlight the mechanism of both infection through the variable (D614G), and the antibody resistance against it, compared to other variables. The results were published the day before yesterday in the journal, “Science Advances” .

“We have found that the interactions between the building blocks of the spike protein, which is the main protein of the virus, that gives it its famous coronary shape, becomes more consistent with the variable,” said Janana Jananakaran, the lead author of the study, in a report published on the website of the Los Alamos National Laboratory, in conjunction with the publication of the study. D614G), and this gives it more opportunities to bind to the receptors in the human host, and at the same time, this gives the antibodies an opportunity to attack the virus. ”

The researchers knew that the variable, also known as (D614G), was more contagious and could be neutralized by antibodies, but they did not know how, and by simulating more than a million individual atoms across supercomputers, the new work provides details on the molecular level about the behavior of the special protein (Spike). Variable (D614G).

The current vaccines for the virus depend on the original form (D614G), and this new understanding of it through the most comprehensive supercomputer simulations at the atomic level may mean that it provides the backbone for future vaccines.

The team discovered the variant (D614G) in early 2020, as the (Covid-19) pandemic, caused by the emerging corona virus, was escalating.

The simulations in this new research show that the interactions between building blocks of the spike protein are more consistent in the new morphology than those in the original shape strain (D614D).





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