The secretion of dopamine in the brain may play a major role in causing corona infection

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Cairo – By Mohamed Salah – As the Coronavirus (COVID-19) pandemic continues to spread worldwide, more information is being revealed about the virus and disease process. According to scientists, it is well proven that the Corona virus enters the body through cell gates, which is the angiotensin-converting enzyme. 2 (ACE2), but now, a team of scientists has revealed that the mechanisms of dopamine release in the brain may play a pivotal role in the entry and spread of corona viruses.

According to the site “sciencedaily”, it aims researchers from the Kingdom of Saudi Arabia Saudi To investigate the contribution of diseases and related drugs to deaths related to COVID-19.

Several studies are currently examining the possible effect of corona on the brain, based on reports of neurological manifestations, other patients who become severely ill, and in rare cases, viral infection also causes neurological symptoms.

It is also known that dopamine receptors are involved in the entry of many viruses, for example, increased levels of dopamine can enhance the onset of human immunodeficiency virus (HIV) and related central nervous system (CNS) infections by stimulating the expression of the entry receptor virus. HIV, which enables the virus to evade the immune system.

Another example is Japanese encephalitis virus (JEV), which is one of the viruses associated with dengue fever, yellow fever, and West Nile viruses. Japanese encephalitis is spread by mosquitoes and can disrupt the blood-brain barrier and cause encephalitis. It also exploits dopamine signals to speed up the infectious process.

The study, which appeared in the Journal of Medical Sciences at Taibah University, showed that the Corona virus may behave similarly to the pathogenic mechanism in the central nervous system from Japanese encephalitis and HIV during the early stages of infection.

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To reach their findings, researchers from King Abdulaziz University and the College of Dentistry at Taibah University in Saudi Arabia studied various clinical scenarios. In this way, they can formulate a theoretical framework for a better understanding of how the central nervous system is infected by the Coronavirus.

The team noted that it is possible that after the initial corona binding to the ACE2 receptor, the virus’ spiny protein binds to the dopamine receptors of neighboring cells, and since the brain contains dopamine receptors, it plays an integral regulatory role in local immunity, such as the release of lymphocytes and cytokines.

Also, dopamine in certain concentrations can disrupt lymphocyte function. When there is an influx of dopamine, it reduces innate and adaptive immunity, and this causes neurological symptoms, including fatigue, dizziness, encephalopathy, and loss of consciousness, among others.

Dopamine is also a regulator of immune function, as the virus may manipulate the immune system by raising levels of dopamine to help them enter cells.

Next, the research team also revealed that high dopamine levels reduce oxygen levels, which is often observed in COVID-19 patients. Dopamine can suppress the respiratory response to the human primary carotid body activity to hypoxia, and thus, corona and dopamine could be responsible for poor ventilation in COVID-19 patients.

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