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The upper respiratory system
Examine the conditions of corona transmission in animal models
The researchers used a reference strain and examined transmission routes and whether immunity acquired through previous infection or vaccination could protect the rodents from infection.
They found that the rodents were almost tolerant of infection with the virus as a result of direct contact with infected animals, after which the researchers used the initial reinforcement strategy and vaccinated the rodents, to determine whether intramuscular vaccination provided protection against infection.
They revealed that none of the vaccinated animals had protection against infection, and no statistically significant differences were found in the levels of RNA or titers of the virus infectious in the nose of rodents.
The results demonstrate that direct contact is the primary method of transmission of the Coronavirus strain in rodents and that immunity is intact for at least 56 days. The study also indicates that only vaccine strategies that mimic natural infection or induce site-specific immunity can provide protection for the upper respiratory tract against the virus.
The study showed that the reference strain used, affiliated with the Centers for Disease Control, is used by multiple research laboratories across the United States, and in this study, the researchers demonstrated that direct contact is the predominant mode of transmission for the Corona strain in rodents, and they also showed that rodents have protection against re-infection even When neutralizing antibody levels are low or undetectable.
Finally, they showed that intramuscular vaccination of the rodents failed to induce adequate antibodies, and the rodents remained vulnerable to infection in the upper respiratory tract, indicating that in order to protect the upper respiratory tract, we need vaccines that mimic the natural Corona infection.
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