A clinical study reported the effectiveness of a form of vitamin B-3 in protecting the skin from the effects of ultraviolet (UV) exposure, which is one of the main risk factors for non-melanoma skin cancer.
Researchers at the Arab University in the province of “Novara” in northern Italy worked on isolating cells (human primary keratinocytes) from the skin of patients with non-melanoma skin cancer, and these cells were treated with three different concentrations of the compound “nicotinamide” (NAM) – a form of vitamin B – 3 “for a period of 18, 24, and 48 hours, then was exposed to ultraviolet light.
The results showed that pretreatment of 24 microns (unit length) of nicotinamide (NAM) 24 hours prior to exposure to UV rays protected skin cells from the effects of oxidative stress from exposure to UV rays, including DNA damage.
Nicotinamide (NAM) was also found to be effective in repairing DNA damage .. Moreover, the compound was successful in reducing antioxidant expression and preventing local inflammation by showing a decrease in nitric oxide (NO) release and reactive oxygen production (ROS). ), As well as reducing iNOS expression.
“Our study indicates that increasing the consumption of vitamin B-3, which is readily available in the daily diet, will protect the skin from some of the effects of exposure to ultraviolet rays, which may reduce it,” said Dr. Lara Camilo, a researcher in the dermatology unit at the Arab Open University in Italy. From the incidence of non-melanoma skin cancer.
However, the researchers cautioned that the protective effect of vitamin B-3 is short-acting, so it should be taken no later than 24 to 48 hours before exposure to the sun.
Non-melanoma skin cancer is the most common malignancy, and it is increasing steadily worldwide.
Exposure to the sun’s harmful UV rays is the main risk factor that destroys DNA, increases production of reactive oxygen species (ROS), stimulates inflammatory responses, as well as depletes cellular energy, which leads to genetic instability and cell death.