Scientists from the United States have discovered that the rhinovirus that causes the common cold can block the influenza A virus.
According to The Lancet Microbe, rhinovirus infection is the most common cold disease and appears in the form of a common cold (runny nose) and lasts 5-14 days.
After researchers from Yale University School of Medicine in New Haven studied and analyzed clinical data and conducted experiments on cultured cells, it became clear to them that the rhinovirus prevents the spread of the influenza A virus. This is a known phenomenon for a long time, but it is observed for the first time between these two viruses.
It is reported that during the 2009 epidemic, the spread of the H1N1 influenza virus slowed in the fall with the onset of seasonal colds. This prompted researchers to search for the reason.
For this purpose, they analyzed the results of PCR tests for adult patients at the University Hospital for the three seasons 2016-2017, 2017-2018 and 2018-2019, using a device that detects ten viruses: rhinovirus, influenza A and B viruses, influenza viruses 1, 2 and 3, viruses. Human metabenomovirus and adenovirus.
The researchers selected 13,707 results and found that influenza A virus and rhinovirus met in similar amounts, 922 and 982, respectively. However, the researchers’ attention was sparked by its presence in only 12 samples. So the researchers tested the mechanism of interaction of the two viruses on respiratory implanted epithelial cells, which they infected with the rhinovirus HRV-01A, and after three days, the influenza A virus from the H1N1 strain. The researchers discovered that 72 hours after the cells were infected with the rhinovirus, their immune response reached its peak, and at the same time 4 genes that stimulated interferon were activated, which encoded the molecules that prevent the influenza A virus.
The results of the experiment showed that the level of suppression of influenza A virus during the initial infection with the rhinovirus is the same as after treating the cells with interferon.
The researchers concluded that the rhinovirus infection blocks the spread of the influenza A virus in the epithelial cells of the upper respiratory tract. This must be taken into account when prescribing drugs and developing a strategy to combat seasonal epidemics. They believe the 2009 H1N1 flu epidemic was stopped thanks to the seasonal epidemic of rhinovirus infection.