Discovery of a relationship between high vitamin D levels and a reduced incidence of chronic disease


the health


Vitamin D.

Serum 25-hydroxyvitamin D (25OHD) concentrations are associated with a reduced risk of developing type 2 diabetes, according to a study published online on August 26th.

The level of 25-hydroxyvitamin D, or 25-hydroxyvitamin D, reflects the amount of vitamin D produced in the skin.

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Ming Wang of Peking University and his colleagues investigated the possible relationship between 25OHD and the risk of developing type 2 diabetes, and whether there was any association modulated by sleep behaviors.

The analysis included 350,211 diabetes-free individuals participating in the UK Biobank, and five sleep behaviors including sleep duration, insomnia, snoring, time pattern and daytime sleepiness were included to generate general sleep patterns, determined by healthy sleep scores. The team also calculated genetic risk scores for sleep patterns.

During 8.1 years, on average, of follow-up, 6,940 cases of type 2 diabetes were recorded.

The researchers found that serum 25OHD was significantly associated with a reduced risk of developing type 2 diabetes (average risk rate, 0.88 per 10 nmol / L increase).

There was also a significant interaction between 25OHD and general sleep patterns on chronic disease risk.

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Daytime drowsiness showed a stronger reaction to 25OHD. The reduced risk of developing type 2 diabetes associated with elevated 25OHD was more pronounced among participants who did not experience frequent daytime sleepiness, compared to those who experienced excessive daytime sleepiness.

The study concluded that higher serum 25OHD concentrations are associated with a lower risk of developing type 2 diabetes, and these relationships are modified through general sleep patterns, where daytime sleepiness is the main contributor.

“Our findings, if confirmed through repetition, may have implications for the development of type 2 diabetes prevention strategies that target improving vitamin D supplementation among people with sleep disturbances, especially daytime sleepiness,” the researchers wrote. .

Source: medicalxpress


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