The research paper recently published in the Journal of the American Society for Microbiology, mBio, explores how HIV attacks peroxyxate (or oxidative particles), and the organelles in all cells that help regulate the immune system, fat metabolism, cardiovascular health, and brain development And nerve function.
“We know that other viruses, including West Nile virus and Zika virus, have many different mechanisms for reducing peroxyases as a way to block the production of interferons, which will prevent most viruses,” said biologist Tom Hopman, a former Canadian researcher with Research Chair on RNA viruses and host interactions. Of reproduction. And all viruses have ways to prevent this interferon response, which is consistent with the idea that peroxisomes are an important goal in terms of viral infection.
The researchers asked whether the virus that causes “covid-19” might infect the peroxisum as well, so they began testing peroxyx-enhancing drugs against the virus in cells.
Hopman said his laboratory collaborated with neuroscientist Christopher Power, in the Research Chair for Neurological and Immune Infection, about 5 years ago, to study why many HIV sufferers suffer from premature aging, a change in the body’s metabolism of fat, and a set of neurological disorders that can To prevent them from living independently.
The team revealed 4 microRNAs in the brains of AIDS patients with dementia.
“Peroxymes may not have been studied as well as they should be, given that they are absolutely necessary for health and growth in humans,” Hopman added, noting that children born with genetic peroxyx disease, Zellweger syndrome, suffer from severe developmental and neurological defects and usually die within a year or two of birth .
Last year, the Hopman Laboratory showed that boosting peroxidase by manipulating genes could prevent the reproduction of the Zika virus. During the next four months, they will continue to test drugs that enhance peroxyx to see if they can do the same against Corona virus and HIV.
Several drugs they try to use as cancer drugs have been approved, but Hopman discovered that they accidentally target a pathway that prevents the formation of peroxisum.
He pointed out that many of the promising treatments against “Covid-19”, including “remediffer”, are relatively expensive and should be given in hospital, while some peroxyx boosters can be taken orally and have few side effects. He said he was excited about the possibility of applying this new approach to combating viral infections.