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The body’s immune cells are a “patrol” of the guard, whose task is to detect and combat foreign bodies. Unfortunately, the “identification system” is not 100% accurate, because immune cells attack healthy tissue cells.
PNAS reports that rheumatoid arthritis is widespread. And people who have it throughout their life suffer from permanent pain and become less mobile. The injured are more susceptible to heart and kidney disease, and suffer from vision impairment and other complications. It has been shown that this disease reduces age on average 3-12 years.
The results of the study, conducted by scientists at the University of Karolinska Swedish Medical, give hope for a therapeutic efficacy that protects humans from arthritis, as they discover a mechanism that may be key to regulating unwanted immune attacks.
In their study, scientists focused on two proteins, interleukin-4 (IL-4) and interleukin-13 (IL-13). They are informative molecules produced by immune cells when allergens or parasitic diseases are present. In order to find effective ways to treat infections and associated disorders.
Swedish scientists used CRISPR to modify the individual genes of immune cells to see how their behavior changed. Experiments have shown that IL-4 and IL-13 influence the behavior of neutrophils, which are immune granular cells, which collect in large numbers in the joints of people with rheumatoid arthritis.
In particular, it has been shown that interleukin 4 and 13 inhibit the migration of immune granular cells to the inflamed joint, and thus hinder their response.
Moreover, these proteins help eliminate arthritis. It turns out that their presence stimulates an increase in receptors on the surface of neutrophils, which hinder the inflammatory process.
Researchers are confident that this discovery will play a major role in developing new treatments for arthritis, especially rheumatoid arthritis.
Source: Veste. Ru